A computational method to design broad-spectrum T cell-inducing vaccines applied to Betacoronaviruses
Palmer P, Fedosyuk S, Parthasarathy S, Holbrook J, George C, O’Reilly L, Weigand L, William Carnell G, Heeney JL, Vishwanath S.
Simultaneous broad protection against Ebola Sudan, Marburg and Lassa viruses conferred by a DNA primed MVA-vectored multivalent vaccine
Kobasa D, Pfranger M, Krause N, Fedosyuk S, Wiegand L, Jordan I, Sandig V, Leupold C, Asbach B, Storisteanu D, Kalender A, Scheer L, Brenner D, Prévost J, Tailor N, Vendramelli R, Warner B, Truong T, Parthasarathy S, Holbrook J, Carnell G, Chan A, Whittaker C, Ugwu C, Happi C, Frost S, Kinsley R, Safronetz D, Wagner R, Heeney JL.
Carnell G, Vendramelli R, Whittaker C, Holbrook J, Parthasarathy S, Stewart H, Olivier J, Warner B, Truong T, George C, Sujit S, Ashokan S, Suau Sans M, Huang C, Wells D, Tonks P, Pfranger M, Einhauser S, Neckermann P, Cantoni D, Chan A, O’Reilly L, Ohlendorf L, Unwins I, Rautenbach S, Ferrari M, Firth A, Geiger J, Dohmen C, Mummert V, Samuel A, Plank C, Del Rosario J, Temperton N, Asbach B, Frost S, Kinsley R, Vishwanath S, Fedosyuk S, Wagner R, Kobasa D, Heeney JL.
Immunogenicity of a trivalent haemorrhagic fever vaccine candidate against Sudan virus, Marburg virus and Lassa virus in an mpox vaccine Open Access
Pfranger M, Krause N, Asbach B, Meier J, Carnell G, Scheer L, Kalender A, Brenner D, Tonks P, Frost S, Wright E, Jordan I, Kennedy E, Hewson R, Blacklaws B, Chan A, Parthasarathy S, Dowall S, Carroll M, Sandig V, Fedosyuk S, Kinsley R, Heeney JL, Wagner R.
Olivier J, George C, Huang C, Sujit S, Tonks P, Cantoni D, Grove J, O’Reilly L, Geiger J, Dohmen C, Mummert V, Samuel A, Plank C, Kinsley R, Temperton N, Pfranger M, Wagner R, Heeney J, Vishwanath S, Carnell G.
Computationally designed haemagglutinin with nanocage plug-and-display elicits pan-H5 influenza vaccine responses
Huang C, Hills R, Carnell G, Vishwanath S, Aguinam E, Chan A, Palmer P, O’Reilly L, Tonks P, Temperton N, Frost S, Tiley L, Howarth M, Heeney JL.
Immunogenicity and Efficacy of Digitally Immune Optimised H1N1 Vaccine Candidates in Swine and Murine Animal Models
Del Rosario J, van Diemen P, Frost S, Vishwanath S, Sujit S, Ashokan S, Mollett B, Ramsay A, Simpson B, Asbach B, Carnell G, Chan A, Tonks P, Temperton N, Davies M, McCauley J, Kinsley R, Wagner R, Everett H, Heeney JL.
Digitally Immune-Optimised Next-Generation Influenza Vaccine Provides Cross-Clade Protection Against Emerging H5Nx Viruses
Heeney JL, Del Rosario J, Vishwanath S, Frost S, Sujit S, Ashokan S, Vendramelli R, Ferrari M, Carnell G, Vianello L, Pagliari M, Ramzi S, Panzarin V, Fortin A, Vascellari M, Truong T, Tonks P, Ortiz A, Huang C, Einhauser S, Schachtner M, Asbach B, Temperton N, Moss R, Davies M, Moss D, Kinsley R, Wagner R, Kobasa D, Bonfante F.
Huang C, Vishwanath S, Carnell G, Chan A, Heeney JL.
A phase I, needle free, dose escalation clinical trial of pEVAC-PS, a candidate pan-Sarbecovirus Vaccine
Munro AP, Ferrari M, Kinsley R, Egan D, Vishwanath S, Bower T, Chan A, Davies M, Rosario JMMD, Moss R, Enever Y, Asbach B, Wagner R, Bousfield R, Chatterjee K, Cornelius V, Faust SN, Heeney JL.
Computationally designed Spike antigens induce neutralising responses against the breadth of SARS-COV-2 variants.
Vishwanath, S., Carnell, G. W., Billmeier, M., Ohlendorf, L., Neckermann, P., Asbach, B., … & Heeney, J. L. (2024). npj Vaccines, 9(1), 164.
Correlation between pseudotyped virus and authentic virus neutralisation assays, a systematic review and meta-analysis of the literature.
Cantoni, D., Wilkie, C., Bentley, E. M., Mayora-Neto, M., Wright, E., Scott, S., … & Temperton, N. J. (2023). Frontiers in Immunology, 14, 1184362.
Vishwanath, S., Carnell, G. W., Ferrari, M., Asbach, B., Billmeier, M., George, C., … & Heeney, J. L. (2023). Nature Biomedical Engineering, 1-14.
Glycan masking of a non-neutralising epitope enhances neutralising antibodies targeting the RBD of SARS-CoV-2 and its variants.
Carnell, G. W., Billmeier, M., Vishwanath, S., Suau Sans, M., Wein, H., George, C. L., … & Heeney, J. L. (2023). Frontiers in Immunology, 14, 1118523.
Influenza A (N1-N9) and Influenza B (B/Victoria and B/Yamagata) neuraminidase pseudotypes as tools for pandemic preparedness and improved influenza vaccine design
da Costa, K. A., Del Rosario, J. M. M., Ferrari, M., Vishwanath, S., Asbach, B., Kinsley, R., … & Temperton, N. J. (2022). Vaccines, 10(9), 1520.
Wells, D. A., Cantoni, D., Mayora‐Neto, M., Genova, C. D., Sampson, A., Ferrari, M., … & Heeney, J. L. (2022). Journal of medical virology, 94(10), 4820-4829.
Heeney, J., Vishwanath, S., Carnell, G., Ferrari, M., Asbach, B., Billmeier, M., … & Frost, S. (2022). Research Square.
Exploiting pan influenza A and pan influenza B Pseudotype libraries for efficient vaccine antigen selection.
Del Rosario, J. M. M., Da Costa, K. A., Asbach, B., Ferrara, F., Ferrari, M., Wells, D. A., … & Temperton, N. J. (2021). Vaccines, 9(7), 741.